Cethromycin

IUPAC: (1S, 2R, 5R, 7R, 8R, 9S, 11R, 13R, 14R ) -8 - [( 2S, 3R, 4S, 6R ) - 4 -dimethylamino -3-hydroxy -6- methyloxan -2-yl ] oxy -2-ethyl - 1,5,7,9,11,13 - hexamethyl -9- [ (E )-3- quinolin- 3- ylprop -2- enoxy ] - 3,17- dioxa -15 -azabicyclo [ 12.3.0 ] heptadecane -4 ,6,12,16 - tetrone

Antibiotic

211-213 ° C

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Cethromycin is a glycoside and antibacterial agent of the ketolides. It inhibits the protein of the bacteria. Cethromycin is currently in Phase III clinical trials (Abbott ) and will be used against infections of the respiratory tract, such as Streptococcus pneumoniae.

Pharmacology

Cethromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It interferes with the 23S rRNA of this subunit by binding to domain II and V. In addition, the formation of the 30S and 50S subunit is inhibited.