Chelidonine

• Stylophorin
• Diphylline

Fixed

About 135 ° C.

Attention

• 34.6 mg · kg -1 ( LD50, mouse, i.v.)
• 125 mg · kg -1 ( LD50, mouse, s.c )
• 360 mg · kg -1 ( LD50, Rabbit, s.c )

Template: Infobox chemical / molecular formula search available

Chelidonine also Stylophorin diphylline or is an oxygen - and nitrogen-containing heterocyclic compound. The alkaloid that occurs ( Chelidonium majus), together with the similar materials Coptisin and berberine in the milky juice of celandine, belongs to the group of benzophenanthridine respectively. Isoquinoline derivatives.

Properties and Uses

Chelidonine is a mitotic poison, but comes across weaker than colchicine. This chelidonine can also be used as a cytostatic and as agents against gram-positive bacteria. As drug chelidonine was, the less analgesic and spasmolytic effect than morphine and papaverine, stomach and intestinal pain and cramps against asthma used. In the Middle Ages the corrosive action of milk sap of the celandine was also used as a remedy for warts.