Chlorophacinone

(RS ) -2 - ( α -(4- chlorophenyl) phenylacetyl ) indan- 1 ,3-dione

Light yellow crystalline needles

Fixed

About 0.6 g · cm -3

138 ° C

240 ° C at 0.8 mbar

Practically insoluble in water ( 3.4 mg · l-1 at 25 ° C)

Risk

• 2.1 mg · kg -1 ( LD50, rat, oral)
• 200 mg · kg -1 ( LD50, Rabbit, transdermal)

Template: Infobox chemical / molecular formula search available

Chlorphacinon is a chemical compound from the group of indane derivatives (more specifically, from 1,3- indanedione ) and organic chlorine compounds.

Production and representation

Chlorphacinon is prepared in various synthetic routes. A frequently used method is based on phenylacetone, which is reacted with bromine in chlorobenzene to 1- bromo-1- phenylacetone. This then reacts with chlorobenzene in the presence of aluminum trichloride under anhydrous conditions, to 1 - (4- chlorophenyl )-1- phenylacetone, which then with dimethyl phthalate in the presence of sodium finally yields the target compound Chlorphacinon.

Properties

Chlorphacinon is a flammable pale yellow solid, which is practically insoluble in water. It decomposes at temperatures above 320 ° C. Outdoors is done fast photolysis. In the bottom of the excavation is carried mainly by ring opening to 4 - Chlordiphenylessigsäure.

Use

Chlorphacinon is used as a rodenticide against field, earth and Rötelmäuse. It works by blocking the blood clotting by blocking the Prothrombinbildung.

In Switzerland, pesticides are allowed that contain Chlorphacinon as active ingredient. In Germany there is no approved pesticides, since the authorization was revoked by the Federal Office of Consumer Protection and Food Safety on 30 June 2010.