Chlortetracycline

• 7-Chlor-4-dimethylamino-1,2,3,4,4a,5,5a,6,12,12a-decahydro-6,10,11,12a-tetrahydroxy-6-methyl-1,3,12-trioxo-2-naphthacencarboxamid
• Aureomycin

• 57-62-5
• 64-72-2 ( chlortetracycline · hydrochloride)

• A01AB21
• D06AA02
• J01AA03
• S01AA02

Yellow, odorless, crystalline solid

Antibiotic

Sparingly soluble in water

Attention

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Chlortetracycline, aureomycin also, is an antibiotic obtained from Streptomyces aureofaciens. It was the first discovered antibiotic in the class of tetracyclines.

History

1945 by the American botanist Benjamin Minge Duggar ( 1872-1956 ) was discovered Aureomycin. Duggar focused his research on microorganisms from the soil. After testing more than 3,500 strains of soil bacteria and fungi, in 1945 he tested a sample of soil from the campus of the University of Missouri. A golden yellow substance produced by soil bacteria and fungi showed antibiotic properties. After extensive testing, he found that the substance against bacilli, staphylococci and streptococci was active. Duggar named the substance aureomycin, from the Latin aureus "golden" and the Greek word mykes, for mushroom (although the producer not a fungus, but a bacterium, the mycelium forms ).

Use

In human medicine, chlortetracycline is used only in two ointments ( Aureomycin ® and Aureomycin ® ointment ) to treat bacterial infections at infected wounds or the outer eye by various strains of bacteria.

In veterinary medicine, chlortetracycline preparations ( CAS Number 64-72-2 usually formulated as chlortetracycline -HCl ) are used in many species for the treatment of infections of the respiratory, urogenital and the gastrointestinal tract, one due to possible development of resistance in advance antibiogram should be created.

Contraindications

In principle has chlortetracycline on similar contraindications such as tetracycline. In veterinary medicine must not be oral administration in ruminants and horses.

Other Information

As part of a three-year study by the University of Paderborn chemists analyzed in a model experiment, inter alia, the way of chlortetracycline in the food chain. It was found that the antibiotics used in animal husbandry are absorbed by the spreading of manure on fields of crops and make their way into food. The preparations were detected in the manure even after 8 months, also succeeded in showing in the upper soil layers of the thus fertilized fields. Even in the root and the green portions of harvestable plants antibiotics could be detected. So, for example, found in the grain of winter wheat traces of chlortetracycline. The leader of this project, Manfred Grote, therefore, said: " The increasing global risks posed by antibiotic resistance can be enhanced by the use of drugs in animal husbandry when antibiotic residues reach not only in foods from animals, but also about crops in the food. "

Trade names

Chlortetracycline is sold in Germany under the name Aureomycin and in Austria in combination with triamcinolone acetonide under the name Aureocort commercially.

Veterinary products are Animedazon spray, Citrolan CTC CTC -HCl and cyclo spray.