Cholestanetriol 26-monooxygenase

Sterol -26- hydroxylase ( CYP27 ) (also Cholestantriol -26- monooxygenase or cytochrome P450 27/25 ) is a mitochondrial enzyme which is important for the reduction of cholesterols to bile acids and with Cytochrome P450 2R1 vitamin D3 to 25 ( OH) vitamin D3 hydroxylated ( it has the enzyme function vitamin D3 25 -hydroxylase ). Mutations at the CYP27A1 gene are responsible for some form of xanthomatosis.

Catalyzed reactions

NADPH / H O2 ⇒ NADP H2O

In addition to reverse cholesterol transport, the oxidation of cholesterol to 27- hydroxycholesterol and release into the blood plasma is the main form of transport cholesterol from the cells out. But the hydroxylation of other cholesterols and vitamin D3 is accomplished by CYP27.

NADPH / H O2 ⇒ NADP H2O

Human Genome Organisation
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