Chromosome 5 (human)

Chromosome 5 is one of 23 pairs of chromosomes in humans. A normal person has two nearly identical copies of this chromosome in most of its cells.

Decryption of chromosome 5

The chromosome 5 consists of 181 million base pairs. A base pair is the smallest information unit of DNA. Chromosome 5 comprising about 6 % of the total DNA of a human cell. The identification of the genes on this chromosome is the part of the ongoing process of the human genome. On chromosome 5 are 900-1300 genes.

Known genes on chromosome 5

The chromosome 5 contains the following genes:

  • CD: CD14 receptor
  • OCLN: occludin
  • SRP19 Signal recognition particle 19 kDa
  • APC: Adenomatous polyposis coli
  • Factor XII Hageman factor
  • FGF: Fibroblast growth factor, such as FGF -18
  • MCCC2: β - subunit of Methylcrotonoyl -CoA carboxylase

Medical importance

With the genes located on chromosome 5, the following genetic diseases or symptoms are associated. These include:

  • Breast cancer
  • Cornelia de Lange Syndrome
  • Distal myopathy 2
  • Familial adenomatous polyposis
  • Kartagener's syndrome
  • Cats cry syndrome (chromosome 5p - syndrome)
  • Colorectal cancer
  • Crohn's disease
  • Myelodysplastic syndrome
  • Oculocutaneous albinism type 4
  • Sotos syndrome
  • Spinal Muscular Atrophy
PLOS Genetics
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