Chromosome 6 (human)

Chromosome 6 is one of 23 pairs of chromosomes in humans. A normal person has two nearly identical copies of this chromosome in most of its cells.

Decryption of chromosome 6

The chromosome 6 consists of 171 million base pairs. A base pair is the smallest information unit of DNA. The chromosome 6 containing about 5.5 % of the total DNA of a human cell. The identification of the genes on this chromosome is the part of the ongoing process of the human genome. On chromosome 6 are 1100-1600 genes.

Known genes on chromosome 6

The chromosome 6 contains the following genes:

  • Factor XIII fibrin-stabilizing factor
  • HSPA1A: Hsp70
  • CDKN1A: p21
  • PKHD1: Polycystic kidney and hepatic disease 1
  • VEGF: Vascular Endothelial Growth Factor
  • MHC / HLA: the major histocompatibility complex / human leukocyte antigen
  • PARK2: parkinson protein 2, E3 ubiquitin protein ligase ( parkin )

Medical importance

With the genes located on chromosome 6, the following genetic diseases or symptoms are associated. These include:

  • Autosomal recessive polycystic kidney disease ARPKD
  • Chondrodysplasia punctata
  • Dyslexia
  • Hemochromatosis
  • Dyslexia
  • Multiple Myeloma
  • Porphyria cutanea tarda
  • Psoriasis vulgaris
  • Sarcoidosis