Chromosome 8 (human)

Chromosome 8 is one of 23 pairs of chromosomes in humans. A normal person has two nearly identical copies of this chromosome in most of its cells.

Decryption of chromosome 8

The chromosome 8 consists of 146 million base pairs. A base pair is the smallest information unit of DNA. Chromosome 8 contains 4.5 to 5 % of the total DNA of a human cell. The identification of the genes on this chromosome is the part of the ongoing process of the human genome. On chromosome 8 are 700-1100 genes. So far, 743 of them are known.

Known genes on chromosome 8

The chromosome 8 includes the following genes:

  • GnRH1: gonadoliberin
  • DNM1, DNM2, DNM3: Dynamine
  • T- PA: tissue -specific plasminogen activator
  • TG: thyroglobulin
  • LPL: lipoprotein lipase

Medical importance

With the genes located on chromosome 8, the following genetic diseases or symptoms are associated. These include:

  • Burkitt's lymphoma
  • Corpus callosum agenesis
  • Diamond - Blackfan syndrome
  • Hereditary spherocytosis (spherical cell anemia)
  • Multiple cartilaginous exostoses
  • Nijmegen breakage syndrome
  • Pfeiffer syndrome
  • Rothmund -Thomson syndrome
  • Trisomy 8 ( Warkany syndrome 2)
  • Waardenburg syndrome
  • Werner Syndrome
Lipoproteinlipase Burkitt's lymphoma
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