Cisapride

( 3RS, 4SR )-4 -amino -5-chloro -N- {1 - [3 - (4- fluorophenoxy ) propyl] - 3- methoxypiperidine -4-yl } - 2 - methoxybenzamide (IUPAC)

• C23H29ClFN3O4 ( cisapride )
• C23H29ClFN3O4 · H2O ( cisapride · monohydrate)
• C27H35ClFN3O10 ( Cisapridtartrat )

• 81098-60-4 ( cisapride )
• 260779-88-2 ( cisapride · monohydrate)

A03FA02

Serotonin (5- HT4 ) receptor agonist

• 465.95 g · mol -1 ( cisapride )
• 484.0 g · mol -1 ( · cisapride monohydrate)

110 ° C.

Risk

4166 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Cisapride is a drug from the group of prokinetic agents which enhance the motility in the upper gastrointestinal tract.

He has been taken in many countries from the market because it caused heart rhythm ( long QT syndrome ). In Germany, the drug was marketed until 2000, under the trade names Alimix and Propulsin.

Chemically, cisapride, a derivative of benzamide. More Specifically, it is a selective serotonin agonist.

Areas of application

Cisapride may be indicated for the symptomatic treatment of heartburn in patients with gastroesophageal reflux disease, also in gastric paralysis in motility disorders of the bowel and constipation.

Effect

Cisapride is a parasympathomimetic which causes a stimulation of 5 -HT4 receptors release of acetylcholine; This leads to different effects in the upper gastrointestinal tract.