Clinically isolated syndrome

In a clinically isolated syndrome (English Clinically isolated syndrome, short- CIS), is a neurological disorder affecting the damage (lesion ) of a circumscribed place in the central nervous system (CNS) can be traced back. The symptoms occurs in this case in terms of thrust. This means that the symptom developed subacute ( within hours to days ) and it is based on an inflammatory- demyelinating injury in the CNS.

Typical examples of symptoms that occur as part of a CIS, blurred vision ( optic neuritis ) and Disorders of emotional feelings ( a spinal localization of the damage which may underlie ) are. Lesions in the brainstem can cause a wide variety of symptoms. In approximately 50 % of patients with isolated optic neuritis develops later in a clinically safe multiple sclerosis. The McDonald criteria indicate how the evidence of spatial and temporal distribution of inflammation, which is necessary for the diagnosis of MS is to lead.

At present it is still unclear what pathogenetic mechanisms cause the transition to a clinically definite MS. However, a key point is likely to be the production of autoreactive T - cells and anti- myelin antibodies by autoreactive B- cells.

• Inflammatory disease of the central nervous system