Cnicin

[(1R,2S,4E,8Z,10S)-8-(Hydroxymethyl)-4-methyl-13-methyliden-12-oxy-11-oxabicyclo[8.3.0]trideca-4,8-dien-2yl] (3S ) -3,4 -dihydroxy -2- methylidene- butanoate

Colorless and odorless solid

Fixed

1.27 g · cm -3 ( 20 ° C, calculated)

142-143 ° C

Slightly soluble in water

Attention

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Cnicin is an unsaturated sesquiterpene Dihydroxylacton which is esterified with a substituted acrylic acid.

Occurrence

Cnicin belongs to the group of germacranolides and is in higher concentration in the blessed thistle ( Cnicus benedictus ), or in panicles Knapweed (Centaurea stoebe ) formed.

The highest and lowest concentrations are found at the leaves ( 0.86 to 3.86 % Cnicin ) or in the trunk.

Effect

The effect of Cnicin is used in the context of phytotherapy. As an effective part in the blessed thistle, it stimulates gastric juice production and is effective against indigestion. Blessed thistle comes in the form of tea infusions or alcoholic extracts used.

Toxicology

Has a high dose Cnicin acute toxic effects in rats, and mice. Furthermore, can cause an overdose of Cnicin to strong irritation in the throat, pharynx and esophagus area. Also, disorders in the gastrointestinal tract to nausea, cramps, vomiting and diarrhea, accompanied by fever, are possible.

Itemization

• Terpene
• Polyene
• Polyol
• Carboxylic acid esters
• Butyrolactone
• Cycloalken