Complementation (genetics)

Complementation (functional supplement ) called each other a statement about the relationship between two gene loci in genetics. By complementation of genetic defects can be compensated. This compensation is done here on a functional level of the encoded proteins, the genetic defect remains.

With the help of the so-called complementation, which is also referred to as cis -trans test, you can try to determine whether two similar mutant phenotypes are caused by a mutation in the same gene or not.

Mutations are A and B at the same gene locus, as is a diploid organism, heterozygous for both mutations ( ie the one A allele and B- allele includes ) the mutant phenotype. A heterozygous ( diploid ) organism, however, can appear with the naturally occurring ( wild-type ) phenotype if the mutations A and B are at different loci that are inherited independently. In this case, complement ( complement ), the residual activities of the wild-type alleles functional.

• Genetics