CTDP1

CTD phosphatase ( FCP1 ) (more precisely, TFIIF associating CTD phosphatase) is the enzyme which catalyzes the phosphate residues of serine 2 and serine 5 Polymerase II removed in eukaryotes during transcription, whereby the polymerase for the elongation (Re- ) is selected. It is a phosphatase. The enzyme is found in humans in all tissue types. Mutations in the corresponding gene can CTDP1 to hereditary multiple developmental disorders with cataracts, cause the so-called CCFDN syndrome.

In order to obtain full activity, the CTD phosphatase is phosphorylated by casein kinase 2 itself, and requires the RAP74 subunit of TFIIF as a cofactor.

Phosphorylation is inhibited by the proteins FCP1 Pin1 and Hce1 and the Tat protein of HIV. FCP1 is methylated by the arginine methyltransferase PRMT5 and FCP1 - PRMT5 complex methylated histone H4.

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