• OMIM: 601 613
  • UniProt: P32302
  • MGI: 103567

CXCR5 (short for CXC motif chemokine receptor 5, also Burkitt 's lymphoma receptor 1 (BLR -1), monocyte -derived receptor 15 (MDR -15), CD185 ) is a receptor protein of the family of chemokine receptors. This receptor is in particular lymphocytes, such as B- and T-lymphocytes before and can be detected in particularly high density cell of Burkitt's lymphoma. CXCR5 is activated by a cytokine CXC motif chemokine CXCL13 (BCA -1) and plays an important role in the targeted attraction (chemotaxis ) of B cells.



CXCR5 is a transmembrane protein is selected from the group of G protein- coupled receptor encoded by a gene on chromosome 11 q23.3 locus. There are two different gene products are known which are caused by alternative splicing.

Receptor activation

CXCR5 is activated by binding of its ligand CXCL13. After activation of the receptor, a forwarding of the signal is independent of Gi proteins by increasing the intracellular calcium concentration.


CXCR5 and its ligand CXCL13 are for the function of secondary lymphoid organs such as lymph nodes, spleen and Peyer's patches, of great importance. An absence of the receptor causes defects in chemotaxis of lymphocytes result. The development of lymph nodes and Peyer's patches is disabled and Primärfolikel exhibit morphologic changes.

CXCR5 can serve as a co- receptor for docking and penetration of HIV virus type 2 ( HIV -2).