After completing his school education, Cyrus Locher studied at Ohio Wesleyan University in Delaware, where he graduated in 1903. He then worked as a teacher and as a school board in Woodsfield, before he began studying law at the University of Michigan and in 1906 received his law degree from the Law School of Western Reserve University in Cleveland. In the same year he was admitted to the Bar Association; In 1907 he then worked as a lawyer in Cleveland. From 1908 to 1910 he served as deputy trial lawyer in the city.
Locher was 1911-1912 member of the teaching staff at Western Reserve University; thereafter he practiced until 1916, the Office of the Public Prosecutor in Cuyahoga County and belonged from 1923 to 1928 as Director of Commerce of the State Government of Ohio. After the death of U.S. Senator Frank B. Willis on March 30, 1928, he was appointed to succeed him; he took his seat in Washington on April 5. Locher, however, applied unsuccessfully for the Democratic nomination for the by-election to this mandate, so he had to leave early as December 14, 1928 the Senate. After that he worked as a lawyer in Cleveland again.