Sanguinetti visited from 1991 to 1992 the Hopman Tennis Academy in Florida and then studied economics for two years at UCLA. His first professional season, he graduated in 1993. Reached by six ATP finals, he won two in 2002 for a Milan against Roger Federer 7:6, 4:6, 6:1, and in Delray Beach against Andy Roddick 6-4, 4:6, 6:4. His only title as a doubles player, he won in 1997 with Dinu Pescariu in Umag. He also won ten Challenger tournaments.
His greatest achievement at a Grand Slam tournament was reaching the quarter-finals of Wimbledon in 1998. From 1998 to 2003 Sanguinetti played for the Italian Davis Cup team and completed a total of 22 matches.