Depurination

Depurination is a spontaneous chemical reaction, which relates to the nucleic acids within the DNA, and in which a purine base, which is either adenine or guanine, will be cleaved from the sugar-phosphate backbone of the DNA double strand by hydrolysis. Phosphodiestergerüst the DNA remains intact during depurination, it may occur as a result of depurination to single-stranded breaks in one strand of DNA. The remaining Apurinposition can be left blank or to be replaced by another, identical or non-identical base.

The depurination occurs predominantly at high heat and in an acidic environment. As part of the base excision repair, the resulting error can be eliminated again.