Dexamethasone

• IUPAC: 9 -fluoro- 11β ,17,21 -trihydroxy- 16α -methyl- pregna -1 ,4-diene- 3 ,20-dione
• Latin: Dexamethasonum

A01AC02, C05AA09, D07AB19, D07XB05, D10AA03, H02AB02, R01AD03, S01BA01, S01CB01, S02BA06, S03BA01

Colorless crystals

Glucocorticoids

262-264 ° C

Hardly soluble in water (89 mg · l-1 at 25 ° C) in ethanol and chloroform

Risk

54 mg · kg -1 ( LD50, rat, ip)

Template: Infobox chemical / molecular formula search available

Dexamethasone ( 9 -fluoro- 16α - methylprednisolone ), is a synthetic glucocorticoid, which has anti-inflammatory and a dampening effect on the immune system. It belongs to the long-acting glucocorticoids, acting around 25 times more potent than the body's own products and has no relevant effect of mineralocorticoids.

With the help of the dexamethasone of the so-called Dexamethasontest (also called Dexamethasonsuppressionstest ) performed to detect elevated serum concentrations of cortisol. A distinction is made between a short-term test with a unique Dexamethasongabe as well as a long term test with a Dexamethasongabe over four days. By dexamethasone cortisol produced amount is reduced because dexamethasone same feedback receptors responsive as cortisol. In this way pathological quantities can be determined. Dexamethasone not falsifying unlike other synthetic steroid hormones cortisol, the chemical laboratory determination.

Dexamethasone may reduce the probability of occurrence of high altitude pulmonary edema in mountaineering at high altitudes. As sports medicine at the Medical University Hospital Heidelberg and the University Hospital Zurich found in a small study in 2006, which means also bends better against altitude sickness before the Potency tadalafil.

Trade names

Afpred - Dexa (D), Axidexa (D), Cortidexason (D), Dexabene (D, A), Dexabeta Injekt (D), Dexacortin (CH), Dexaflam Injekt (D), Dexafluid eye drops (D), Dexafree (CH ), Dexaloscon (D), Fortecortin (D, A, CH), InfectoDexaKrupp (D), Isopto -Dex (D), Lipotalon (D), Maxidex (CH), Mephameson (CH), Monodex (D, A), Solupen (D) Solutio Cordes Dexa (D), Spersadex (D, CH), Toto corticosteroid (D), Tuttozem (D)

Corti Biciron (D), Cortidexason comp. (D), Dexa Biciron (D), Dexa - Gentamicin (D), Dexagent (D), Dexalocal (CH), Dexasalyl (CH), Dispadex (D), Doxyproct (CH), Frakidex (CH), Isopto -Max (D), Maxitrol (CH), Multodrin (A), Nystalocal (D, CH), Otobacid (D), Pigmanorm (CH), Polydexa (CH), Rheumesser (A), Sebo - Psor (CH), Spersadex comp. (CH), Supertendin (D), Terracortril (D) Tobradex (D, A, CH), Uromont (A) as well as the mono-and combination preparations numerous generic