Diisopropyl azodicarboxylate

• Diisopropylazodicarboxylate
• DIAD

Reddish, pungent-smelling liquid

Liquid

1.03 g · cm -3

3-5 ° C.

75 ° C ( 0.4 hPa)

1.04 hPa

Insoluble in water

Attention

2150 mg · kg -1 ( LD50, Rabbit, transdermal)

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Diisopropyl azodicarboxylate is a reagent for the Mitsunobu reaction. The compound can be used as an alternative for the explosive compound diethyl azodicarboxylate.

Production

They can be prepared analogously to the synthesis routes to diethyl azodicarboxylate, where instead of the appropriate starting materials ethylgruppensubstituierten containing the isopropyl compounds.

Chemical Properties, Safety

DIAD is much less thermally unstable compared to diethyl azodicarboxylate. The connection is not explosive as defined in the Explosives Act. In the steel tube test, an explosion is provided with a nozzle diameter of more than 1 mm. There is no propagation of detonation in BAM 2 "pipe test. The connection is not sensitive to impact. Dealing with the substance under thermal stress is still not safe. Decomposition proceeds in terms of a thermal runaways with a significant heat release. A purification by distillation of connection should be considered only after appropriate safety analysis taking into account the decomposition behavior into account.