Doramectin

25 -cyclohexyl- 5-O- dimethyl- 25 -de (1- methylpropyl) avermectin A1a

QP54AA03

Antiparasitic

Increase in membrane permeability to chloride

Risk

50-100 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Doramectin is a macrocyclic lactone, and glycoside. It counts as a drug to the group of avermectins ( fermentation product of Streptomyces avermitilis ) and is closely related to ivermectin, however, by an additional cyclohexyl group more effective. Doramectin is used in veterinary medicine as an antiparasitic agent.

Chemical Properties and Pharmacology

Doramectin is highly lipophilic and well in many organic solvents, sparingly soluble in water, however.

Like all avermectins increasing the membrane permeability of the nerve cells in nematodes and of nerve and muscle cells in arthropods for chloride ions (see ivermectin). Doramectin therefore acts as Breitspektrumantiparasitikum and has both wurmabtötende ( vermicidal ) as insect-and milbenabtötende properties. Opposite suction and tapeworms of the drug, however, is not effective.

Doramectin is usually administered subcutaneously and is distributed in all tissues, with the highest concentration occurring in adipose tissue. When applied topically, the bioavailability is clearly lower. The plasma half-life is 10 days. Excretion is primarily through the bile and then via the faeces.

Contraindications

Doramectin is well tolerated, not carcinogenic or mutagenic. It can also be used in pregnant and young animals. In dogs with the MDR1 defect, however, the funds should not be used.

Trade names

Dectomax ad us. vet., Dectomax 0.5 % pour-on solution ad us. vet., Doramec L.A., L.A. Dora Quest Oral Gel