Doxazosin

• (RS ) -1 - ( 4-amino- 6,7- dimethoxyquinazoline -2-yl ) - 4 - (2,3 -dihydro-1 ,4- benzodioxin - 2- ylcarbonyl ) piperazine
• DL -1-( 4-amino- 6,7- dimethoxy -2- quinazolinyl ) - 4 - [ (2,3- dihydro -1 ,4- benzodioxin - 2-yl ) carbonyl ] piperazine

• 74191-85-8 ( doxazosin)
• 77883-43-3 ( doxazosin methanesulfonic acid salt)

C02CA04

Alpha blockers

α1 -adrenoceptor antagonist

289-290 ° C ( doxazosin · hydrochloride)

• > 1000 mg · kg -1 ( LD50, rat, oral)
• > 1000 mg · kg -1 ( LD50, mouse, oral)

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Doxazosin is a drug from the group of alpha-blocker that is used for the treatment of benign prostatic hyperplasia and arterial hypertension.

Clinical information

Doxazosin selectively blocks α1 - receptors thus making it comes to peripheral vasodilation and a decrease in blood pressure.

Further, it causes a lowering of serum cholesterol.

Pharmacological properties

Side effect

Among other things, it can come at the beginning of treatment with doxazosin to a sharp drop in blood pressure with dizziness and headache ( " first-dose effect"). Orthostatic hypotension is characteristic of an alpha-blocker.

Other information

Doxazosin has been patented as α1 - sympatholytic 1979/1980 by Pfizer and is available as a generic in the trade. Doxazosin from which the hydrochloride and mesylate is used is structurally related to prazosin.