Drug-induced hyperthermia

As drug fever ( also medications fever) is referred to an increased body temperature ( fever). This increased body temperature is caused by adverse effects of medication and usually occurs between seven and ten days after initiation of therapy. Approximately 10% of inpatient drug- treated patients affected by drug fever.


In question for the emergence of a drug fever, different mechanisms. Examples are:

  • Anaphylaxis ( allergic reactions)
  • Idiosyncrasy ( congenital drug hypersensitivity)
  • Compound-related effects
  • Other changes in thermoregulation

Triggering drug

Almost any drug can cause allergic reactions. Substance Conditional drug fever is but due to the pharmacological action of the drug. The compound-related drug fever is dose-dependent and often occurs with the following groups of substances:

  • Chemotherapeutic agents (eg cytostatics)
  • Antibiotics (such as cephalosporins, penicillins, streptomycin, colistin, vancomycin )
  • Antifungal agents (such as amphotericin B)
  • Centrally acting drugs (such as procarbazine, carbamazepine, phenytoin, methyldopa, halothane, succinylcholine )
  • Thyroid hormone (L- thyroxine)
  • Biologics ( infliximab, filgrastim, etc. )
  • Various other: quinine, nifedipine, procainamide, ranitidine


Suspect medications should be discontinued ex juvantibus. A decrease in temperature indicates a connection, but does not prove anything. Sure you can go when a Reexpositionsversuch is positive. The attempt of re-exposure is not always reasonable or practicable and in any way connected with risks. Standing therapeutic alternatives available, is not generally a rechallenge.

Differential Diagnosis

If no infectious and / or inflammatory causes of fever found ( and be ingested drugs ), drug fever in the differential diagnosis is considered. The fever can often be placed in temporal association with the regulation of new drugs, but all other causes should be (eg tumor fever), which can cause fever, anxious.