Drug intolerance

An intolerance (Latin intolerantia, " bear " of tolerare, " stand " with nay prefix in - ), often called fuzzy " intolerance " or " adverse reaction ", in medicine is a causally diverse group of metabolic disorders due to insufficient processing of supplied or released substances, often by defective enzymes or enzyme deficiency ( enzymopathies ).

The intolerance is manifested by symptoms of poisoning, if a certain substance in, fed itself normal, dosage or there is a 'normal per se, concentration of a particular substance.

Here, the immune system (as opposed to real allergy) or mediators such as histamine (as opposed to pseudo-allergy ) by definition not involved. As a pathological mechanisms in addition to the enzymopathies also Komplementaktivierungen, excessively labile cell membranes of mast cells and basophils or metabolic disorders of arachidonic apply.

Examples are

• Food intolerances such as the lactose intolerance in lactose intolerance and

If it is in case of intolerance to cause a wrong or too little formed enzyme, then one speaks of a idiosyncrasy or idiosyncratic enzymopathy ( eg in the case of lactose intolerance ).

Swell

• Pathophysiology