At the Junior World Championships in 1990, he finished seventh in the 400 -meter run. At the 1992 Olympics in Barcelona qualified in the 4 x 400 - meter relay, the British team in the cast Mark Richardson, Kriss Akabusi, Roger Black and Ladejo in 3:01,20 minutes behind the relay Trinidad for the final. In the finals, David Grindley and John Regis competed for Richardson and Ladejo and took third place behind the United States and Cuba. Richardson and Ladejo were also honored as the lead starter with the bronze medal.
1993 Ladejo won his only British championship, but retired at the World Athletics Championships in Stuttgart in semis; the relay did not qualify for the final.
1994 succeeded Ladejo the breakthrough into the world top. In the Indoor Athletics Championships in Paris, he won in 46.53 s gossamer before the Russians Mikhail Vdovin. In mid-August he won at the European Athletics Championships in Helsinki gold in 45.09 s before the defending champion Roger Black and the Swiss Mathias Rust wood. The British relay in the occupation of David McKenzie, Brian Whittle, Black and Ladejo won in 2:59,13 min well before the French and the Russian relay. A week later took Ladejo, starting for England at the Commonwealth Games in Victoria over 400 m in 45.11 s silver behind the Kenyans Charles Gitonga. The English relay with McKenzie, Peter Crampton, Adrian Patrick and Ladejo won the final in 3:02,14 minutes before the squadrons of Jamaica and Trinidad.
After a rather mediocre season 1995 Ladejo returned at the European Indoor Championships in 1996 back in Stockholm and won clearly in 46.12 s. At the British Championships in Birmingham Ladejo s ran a personal best in 44.66 and was second behind Roger Black. At the Olympic Games in Atlanta Ladejo difference over 400 meters already in the quarter- finals. The relay won her lead in the cast Ladejo, Jamie Baulch, Mark Hylton and Mark Richardson, in the occupation of Iwan Thomas, Baulch, Ladejo Richardson and they also won the semi-finals. In the finals, Thomas, Baulch, Richardson and Black took second place behind the relay from the United States. Mark Hylton and Ladejo were also honored with the silver medal.
After Atlanta was Ladejo only once in a grand finale. At the IAAF World Indoor Championships in Lisbon in 2001, he belonged to the British relay that finished the race in fifth. Because of the doping Falls Jerome Young the baton later moved to a place.
Du'aine Ladejo is 1,86 m tall and weighed about 83 kg competition times. A graduate of the University of Texas competed for the Birchfield Harriers.