Enilconazole

  • (RS ) -1 - ( 2 - ( allyloxy ) -2 - (2,4- dichlorophenyl) ethyl) - 1H-imidazole
  • Chloramizol
  • Deccozil

QD01AC90

1348 kg · m-3

50 ° C.

367 ° C

In water 1.4 g · l-1

Risk

  • 227 mg · kg -1 ( LD50, rat, female. , Oral)
  • 343 mg · kg -1 ( LD50, Rat, male, oral)

Template: Infobox chemical / molecular formula search available

Imazalil - INN enilconazole - is a systemic fungicide from the group of imidazoles. It was developed by the Belgian company Janssen Pharmaceutica. The substance is also sold in the form of their salts, for example as imazalil - nitrate (CAS 33586-66-2 ) or imazalil sulfate ( CAS 58594-72-2 ).

Operation

Imazalil inhibits the biosynthesis of ergosterol, which increases the cell membrane of fungi. Therefore, it is protective and curative against many fungal pathogens.

Use

Plant protection

Imazalil is used in the cultivation of fruits, vegetables and ornamental plants. The substance is contained in seed dressings for cereal seed. She has a good effect against the stripe disease in barley.

In Switzerland, imazalil may be used in the greenhouse in the form of incense against powdery mildew on tomatoes and cucumbers. It is also part of an approved product for the treatment of seed potatoes. It is also included in wound closure products for fruit and ornamental trees. In Germany imazalil is only allowed for dressing of cereal seed. In Austria imazalil is used in addition to the seed treatment also for the protection of seed potatoes before Fusarium storage decay, Phomafäule and silver scurf.

Preservative

Similar to thiabendazole, imazalil, ortho- or biphenyl protect citrus fruit against mildew. As far as they are subject to the EU marketing standards, citrus fruits treated must be identified with imazalil. Treated bowls should not be eaten. Imazalil has no E-number so far.

Veterinary medicine

In veterinary medicine, imazalil is under the brand name Imaverol ad us. vet. used as Breitspektrumantimykotikum to treat fungal infections of the skin ( superficial mycoses ) and the nose, in birds against guttural pouch mycosis. It is administered locally ( topically ).

Toxicology

Experimental animals were given as a symptom of acute poisoning creeps. Imazalil seems to energize the hair follicles on the nervous system. In addition, there were coordination problems, low blood pressure, tremors and vomiting. In some susceptible individuals contact dermatitis occurred. The LD50 for oral intake was 227 mg / kg body weight ( female rats ) and 343 mg / kg body weight ( male rats ).

In long-term studies in rats appeared slightly altered liver enzymes, weight gain was reduced and there were effects on bilirubin budget detectable. Otherwise, no effect of imazalil doses were observed.

Imazalil is metabolized in the body and excreted within a few days, it does not accumulate in the fatty tissue. WHO indicates a permitted daily dose of 0.03 mg / kg / day.

From the U.S. Environmental Protection Agency imazalil is classified as probably carcinogenic in animal experiments because combined adenomas and adenomas of the liver were performed with carcinomas. In rats, it was found after the administration of imazalil also adenomas and carcinomas of the thyroid. A possible increased risk in the opinion of the EPA only for people who deal directly with imazalil or pack citrus fruit.

In mice imazalil led to reproductive and developmental disorders.

In their MSDS, the Bayer attention to the toxicity of the pesticide against trout: therefore die at an exposure time of 96 h and a water concentration of 1.48 mg / l 50 % of the test organisms.

Environmental effects

Birds are relatively insensitive to imazalil, the LD50 for ducks or quail is about 6000 mg / kg body weight. For fish, it is toxic, however, the LC50 for trout is 2.5 mg / L. For bees, an oral LD50 of 40 micrograms / bee was determined so that imazalil is deemed not to bee -toxic.

The half-life for degradation in the soil is about half a year. Imazalil remains in the soil and will not wash out.

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