Ependymin

• UniProt: P17561

Ependymin is a glycoprotein that has been isolated in the brain of teleost fish from the ependymal cells and from the extracellular fluid. Is an adhesion molecule. In amphibians, mammals and man -like molecules have been found which are called ependymin related proteins (ERP).

Ependymin occurs in two glycosylation variants: a 31 kDa mono-N- glycosylated form of 37 kDa and a bi- N -glycosylated form. In the cerebrospinal fluid and the extracellular matrix of the goldfish Ependymin occurs with 15% protein content and can be detected as a mono -, di- and polymer, wherein the monomers are stabilized by calcium ions and the dimers by zinc ions. Although Ependymine are produced in the fibroblasts of the meninx, you can find them again also on neurons.

The biological functions of Ependymine are still largely unknown. You could be involved in memory consolidation, since it could be shown that they had an increased turnover after a vestibulomotorischen conditioning of goldfish. Ependymine appear neither in learning nor in short term memory, yet at the memory capacity of goldfish involved only in the consolidation of long-term memory.