Epibatidine

• ( )- Epibatidine
• (1R, 2R, 4S ) - ( ) -2 - ( 6-chloro -3-pyridinyl )-7- azabicyclo [ 2.2.1] heptan

White solid [( )- epibatidine dihydrochloride · ]

Liquid [( )- epibatidine ]

216-217 ° C. [( ) - epibatidine dihydrochloride · ]

Poorly in water (10 g · l-1 [( )- epibatidine dihydrochloride · ] )

Risk

[( ) - Epibatidine dihydrochloride · ]

Template: Infobox chemical / molecular formula search available

Epibatidine is a glandular secretion from the skin of poison dart frog ( Epipedobates tricolor) derived alkaloid with bicyclic structure. It is present in an amount of less than 1 mg per frog. Epibatidine exceeds the analgesic effect of morphine to about 200 times, and the affinity of nicotine to nicotinic acetylcholine receptors to 120-fold. Epibatidine is a potent analgesic, however, too toxic for use in humans.

Starting from the epibatidine only slightly toxic non-opioid analgesic ABT -594 was developed in 1996, is among the azetidines.