Epirubicin

• ( 8R, 10S) -10 - [( 2S, 4S, 5R, 6S )-4- amino-5 -hydroxy- 6-methyl- oxan -2-yl ] oxy - 6,11- dihydroxy- 8-( 2 - hydroxyacetyl ) - 1 -methoxy- 8-methyl- 9,10- dihydro- 7H- tetracene -5 ,12- dione ( IUPAC)
• Epirubicini hydrochloridum

• C27H29NO11 ( epirubicin )
• C27H29NO11 · HCl ( epirubicin · hydrochloride)

• 56420-45-2 ( epirubicin )
• 56930-09-1 ( epirubicin · hydrochloride)

L01DB03

Orange - red crystals ( epirubicin · hydrochloride)

Anthracyclines

DNA intercalation, topoisomerase II inhibition

• 543.52 g · mol -1 ( epirubicin )
• 579.98 g · mol -1 ( epirubicin )

Fixed

185 ° C ( decomposition) ( epirubicin · hydrochloride)

Very poor in water ( 93 mg · l -1)

Template: Infobox chemical / molecular formula search available

Epirubicin is an organic chemical compound that is one of the derivatives of anthraquinone and the glycosides. The off-white, crystalline powder decomposed by sunlight and is hydrolyzed in the presence of water.

Epirubicin is as hydrochloride (trade name: Farmorubicin (Pfizer ), and others) used as a cytostatic agent. Chemically, it is a semisynthetic derivative of daunorubicin (including adriamycin ) and counts to the group of anthracyclines. Epirubicin hydrochloride since the 1980s in clinical use and is for intravenous use in the chemotherapy of breast cancer ( breast cancer), non-Hodgkin's lymphomas, sarcomas, gastric carcinoma and other solid cancers.

Epirubicin and adriamycin act by direct DNA damage and inhibition of DNA polymerase and RNA polymerase cytotoxic and mutagenic. The cardiotoxicity of epirubicin is lower than daunorubicin.

The spectrum of adverse effects similar to that of other anthracyclines. The following may occur: allergies, cardiomyopathy ( dose-dependent ), bone marrow depression (blood image degradation ), nausea, vomiting, hair loss, including m.