Esomeprazole

• (S )-5- methoxy-2- [(4- methoxy- 3.5 - dimethylpyridin -2-yl ) methylsulfinyl ] benzimidazole
• Perprazol
• Latin: Esomeprazolum

A02BC05

Proton pump inhibitors, Ulkustherapeutika

An inhibitor of the proton- potassium pump

Template: Infobox chemical / molecular formula search available

Esomeprazole is a prescription drug from the group of proton pump inhibitor that is used in medicine, including the treatment of gastric and duodenal ulcers and reflux oesophagitis in ( an inflammatory disease of the esophagus ). Esomeprazole has been put on the market (now AstraZeneca) in German speaking countries ( Germany, Austria, Switzerland ) under the trade name Nexium ® by Astra. Meanwhile, there are also several generic.

• 2.1 Chemical Information
• 2.2 dismissal from the prescription

Pharmacological properties

Mechanism of action ( pharmacodynamics )

With respect to the racemate, the effect is enhanced, whereby this gain is given by a somewhat lower rate of metabolism and thus extended availability, while the two enantiomers of omeprazole does not even have different efficacy. Expressed succinctly by the pharmaceutical information from the publishing house of the Austrian Medical Association: " omeprazole in a slightly higher dose has the same effect and side effects such as esomeprazole. Who takes the cheaper omeprazole in a slightly higher dose, also has swallowed enough Nexium. "

Other Information

Chemical information

Esomeprazole, the ( S)- enantiomer of omeprazole ( qv) and as applied in this form of enteric-coated tablets or as an infusion.

Dismissal from the prescription

In the U.S., esomeprazole was released in March 2014 from the prescription. We call this change in the pharmaceutical industry, " Switch".

Trade names

Monopreparations: Esomep, Nexium, Durotiv

Combined preparations: Vimovo ( esomeprazole contains the painkiller naproxen )