Fenbendazole
Methyl-5- (phenylthio )-2- benzimidazole carbamate
QP52AC13
Anthelmintic
Mikrotubuliinhibitor
233 ° C
Poorly in water
> 1000 mg · kg -1 ( LD50, rat, oral)
Template: Infobox chemical / molecular formula search available
Fenbendazole is a broad spectrum anthelmintic from the group of benzimidazoles. It is used in veterinary medicine as a remedy for internal parasites. Also combination products with praziquantel are available.
Mechanism of action
Fenbendazole has a broad spectrum of activity against roundworms ( nematodes) and tapeworms ( cestodes ). It acts relatively slowly, so that a sufficiently long contact time must be guaranteed to worm. In animals with faster intestinal transit ( carnivores ) therefore has the means less good.
Like all benzimidazoles is Fenbendazole binds to tubulin, a protein subunit of microtubules, the parasite cell ( Mikrotubuliinhibitor ). This results in damage to the cytoskeleton, intracellular transport, and whereby synthesis processes to be disturbed (in particular glucose transport and ATP synthesis). The parasite formally starved and dies and is excreted in the feces. By inhibiting the formation of the spindle apparatus and disorder of metabolism during embryogenesis the agent is also effective against the eggs of the worms ( ovozid ).
In tapeworms it comes to damage to the Saugstrukturen, so come off the parasites after four to eight hours of the intestinal wall and are eventually excreted in the feces.
Fenbendazole is not absorbed in the intestine.
The medication works against all relevant nematodes. In addition, it is also against some types of rights tapeworm ( Taenia species and Monezia ), liver fluke, Trichinella and Giardia and Encephalitozoon cuniculi against loss.
Contraindications and side effects
Pregnant animals should not be treated with fenbendazole, especially the use in Frühträchtigkeit is contraindicated. In birds, it should not be used during the spring change ( Mauser ).
The product is very well tolerated, even when a tenfold overdose usually remains asymptomatic. In domestic dog and domestic cat can occur as a side effect rarely vomiting. With domestic pigeons, when used in the Mauser spring formation damage can occur.
Trade names
- Monopreparations: Ascapilla , Coglazol, Fenbendatat, Feligel, Orystor, Panacur
- Combination preparations with praziquantel: aniprazol KH, Bihelminth mv, Caniquantel, Fenprasel, Fenquantel, Prazifen combi, vermis -Ex