Fludarabine

• {[( 2R, 3S, 4S, 5R ) -5 - ( 6-amino -2-fluoro -9H -purin- 9-yl ) -3,4- dihydroxyoxolan -2-yl ] methoxy } phosphate ( IUPAC)

• 75607-67-9
• 21679-14-1 ( of phosphate)

L01BB05

Soluble in DMSO

Of phosphate

Attention

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Fludarabine is an antineoplastic agent from the group of purine analogs.

Properties

Fludarabine or fludarabine phosphate ( fludarabine 5 dihydrogen phosphate ) is a fluorinated nucleotide analog of vidarabine and belongs to the group of purine analogues. It comprises - in contrast to most of the nucleotides - in place of the β -D - ribofuranose, the β - D - arabinofuranose. Further, the adenine is substituted at the 2-position with fluorine.

Fludarabine is phoshoryliert after intravenous administration in the body cells to the active metabolite of fludarabine - ATP. In this form it is actually effective. It prevented for DNA synthesis by inhibiting ribonucleotide reductase and DNA polymerase. In addition, the fludarabine nucleotide is incorporated into DNA and thus leads to apoptosis of the cell. Fludarabine thus has cytotoxic properties.

Use

Fludarabine is used for the treatment of low -grade non -Hodgkin's lymphoma, acute leukemia and chronic lymphocytic leukemia ( CLL).

Side effects

Major side effects include myelosuppression and often pronounced immunosuppression, which leads to an increased susceptibility to infections. Through a frequently occurring bone marrow anemia, thrombocytopenia and neutropenia may occur. There are often reduced CD4 helper cells, CD8 suppressor cells and natural killer cells (NK cells ), and the immunoglobulins. Also, can occur as with other cytotoxic drugs nausea, loss of appetite, weakness and fever.