Flunarizine

• IUPAC: 1 - [ bis (4- fluorophenyl) methyl] -4 - [ (2E )-3- phenylprop -2 -en- 1-yl ] piperazine

• C26H26F2N2 ( flunarizine )
• C26H26F2N2 · 2HCl ( flunarizine dihydrochloride · )

• 52468-60-7 ( flunarizine )
• 30484-77-6 ( flunarizine dihydrochloride · )

N07CA03

Calcium antagonist

Calcium channel inhibitors

• 404.49 g · mol -1 ( flunarizine )
• 477.42 g · mol -1 ( · flunarizine dihydrochloride)

251.5 ° C ( flunarizine dihydrochloride · )

Attention

960 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Flunarizine is a drug which is used in the prophylactic treatment of migraine and in the treatment of vertigo. Flunarizine is a calcium channel blocker, which additionally has effects as H1 antihistamine, anti-convulsant and anti-arrhythmic. Flunarizine also acts as FIASMA ( functional inhibitors of acid sphingomyelinase ). The drug was discovered in 1967 by the pharmaceutical company Janssen Pharmaceutica.

Clinical information

Indications ( application areas)

Flunarizine is approved for the prophylaxis of migraine with or without aura diagnosed when the migraine cases lead to a corresponding suffering because of their frequency or severity. In addition, a regulatory drug approval for the symptomatic treatment of vertigo as a result of persistent disorder of the vestibular system.

Contraindications ( contraindications)

Flunarizine may not be used in patients with known intolerance to the drug, Parkinson's disease, or history occurred other extrapyramidal motor disturbances. Flunarizine is also contraindicated in patients with known depressive syndromes in prehistory. In children flunarizine lack of experience should not be used.

Interactions

Concomitant intake with alcohol or drugs with a sedative effect - such as sedatives or tranquilizers - can increase the sedating side effects of flunarizine to be strengthened.

Adverse drug reactions

With over 10% of patients fatigue, increased appetite and weight gain were observed as the most common side effects. Uncommon ( 0.1-1 % of patients) have been reported more central nervous system side effects such as insomnia and anxiety. Just as often, can gastrointestinal side effects, such as heartburn, nausea, stomach pain, and headache and asthenia may occur. Galactorrhea, dry mouth, muscle pain and skin redness have been reported in very rare cases ( < 0.01 %).

Rare but serious side effects can occur with flunarizine during long-term treatment. These include episodes of depression and Parkinson -like symptoms, such as extrapyramidal motor disturbances, bradykinesia, rigidity, tremor, orofacial dyskinesia, akinesia and akathisia, a. In these cases, further treatment with flunarizine should be discontinued.

Trade names

Monopreparations: Flunavert (D), Natil -N ( D), Sibelium (A, D, CH), generics (D) The commercial preparations contain flunarizine dihydrochloride ·.