Fluoroacetic acid

• Monofluoroacetic acid
• MFA
• Fluoro acetic acid (IUPAC)

Colorless and odorless solid

Fixed

1.37 g · cm -3 ( 60 ° C)

35 ° C.

168 ° C.

5.3 hPa ( 36 ° C)

2.59 (25 ° C)

Soluble in water

Risk

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Fluoroacetic acid is a fluorinated organic compound is selected from the group of carboxylic acids. The highly toxic substance is manufactured for rodent control. In poison baits are usually not the free acid, but its salts ( Monofluoracetate ) are used.

Occurrence

In nature there is the sodium salt sodium fluoroacetate as a toxic ingredient in the leaves of a South African shrub " Gifblaar " ( "poison sheet " Dichapetalum cymosum ). The consumption of the plant can lead to livestock poisoning. The colorless, crystalline substance decomposes on heating.

Production and representation

Fluoroacetic acid is followed by reaction of Methyliodacetat and silver (I ) fluoride and potassium fluoride, or methyl chloroacetate of ester hydrolysis can be obtained.

Toxicology

Fluorine substituted acetic acid in the Krebs cycle and leads to the level of citrate / cis- aconitic for enzyme blockade (via the metabolite Fluorocitrat ) and is therefore highly toxic. The lethal dose for humans about 5 mg · kg -1. In rodents, such as mouse or rat, which have a correspondingly higher metabolism, the dose is significantly lower at 0.1 mg · kg -1. Compared to fish and aquatic invertebrates is the connection but virtually non-toxic.