Fluphenazine

4 - [3 - (2- Trifluormethylphenothiazin -10 -yl ) propyl ]-1- piperazinethanol

  • C22H26F3N3OS ( fluphenazine )
  • C22H26F3N3OS · 2HCl ( fluphenazine dihydrochloride · )
  • C32H44F3N3O2S ( fluphenazine decanoate · )
  • 69-23-8 ( fluphenazine )
  • 146-56-5 ( fluphenazine dihydrochloride · )
  • 5002-47-1 ( fluphenazine decanoate · )

N05AB02

White solid ( dihydrochloride)

Neuroleptic

  • 437.52 g · mol -1 ( fluphenazine )
  • 510.44 g · mol -1 ( fluphenazine dihydrochloride · )
  • 591.77 g · mol -1 ( fluphenazine decanoate · )

235-237 ° C or 224.5 to 226 ° C ( fluphenazine dihydrochloride · )

Risk

220 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Fluphenazine is a drug from the group of phenothiazines, which is used as a neuroleptic. It was the first drug in the depot neuroleptic, which was introduced in 1967 as Prolixin in the USA.

  • 2.1 Chemical and pharmaceutical information
  • 2.2 history
  • 2.3 Doping
  • 2.4 Side Effects

Clinical information

Areas of application (indications )

Fluphenazine is an antipsychotic, which is for oral and parenteral administration in the trade. It is used:

  • As long-term therapeutic agent for symptom suppression in chronic schizophrenic psychoses and prevention of relapse in schizophrenic psychoses phasic
  • In acute psychotic syndromes with delusions, hallucinations, thought disorder, disorganization of thought and ego disturbances
  • In catatonic schizophrenia
  • With chronicity of the endogenous psychoses ( symptom suppression and prevention of relapse )
  • For the treatment of psychomotor agitation

Other Information

Chemical and pharmaceutical information

Fluphenazine, starting from 1, in a multi-step synthesis - (3 -hydroxypropyl ) -piperazine.

History

Fluphenazine was introduced in 1961 in tablet form under the trade names OMCA and Lyogen in Germany. Fluphenazine in 1968 was brought under the trade name Dapotum -D as the first depot neuroleptic on the market. Fluphenazine is now available as a generic in the trade.

Doping

Fluphenazine is used in veterinary medicine as a sedative, in addition to the anesthesia preparation, for example, to immobilize animals during transport. The use of fluphenazine to calm the horses in dressage competitions, however, is prohibited as doping.

Side effects

The adverse side effects is one of the so-called extrapyramidal syndrome, which has strong similarities to motor changes that occur in Parkinson's disease, such as muscle stiffness, tremor, slow motor skills and restlessness. Some of these symptoms usually resolve after discontinuation of the drug. However, it can also lead to lasting and sometimes permanent motor disorders.

Trade names

Lyogen (D) and a generic (D)

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