Foscarnet

Phosphonoformic

• 34156-56-4 ( trisodium salt hexahydrate )
• 63585-09-1 ( trisodium salt)

J05AD01

Virostatikum

DNA polymerase inhibitor

Attention

Template: Infobox chemical / molecular formula search available

Foscarnet is an antiviral effective drug ( antiviral agent ), which is mainly used for the treatment of herpes viruses, including cytomegalovirus, but is also effective against hepatitis B virus and HIV. Foscarnet is under the brand names Foscavir ® (D, CH) and Triapten ® ( D) sold and is subject to medical prescription.

Pharmacology

Areas of application

Foscarnet is approved for the systemic treatment of a life - threatening disease and eyesight by cytomegalovirus and for the treatment of acute mucosal infections caused by herpes viruses aciclovirresistente in patients with AIDS. The application is carried out intravenously; The half-life in blood is 3.3 to 6.8 hours. In addition, foscarnet locally for the treatment of skin and mucosal infections caused by herpes simplex virus types 1 and 2, such as herpes labialis, genital herpes and herpes integumentalis be used.

Mechanism of Action

Foscarnet is an analog of pyrophosphate. As such, it blocks the Pyrophosphatbindungsstelle of DNA polymerase and reverse transcriptase, and is thus a selective inhibitor of the viral enzymes.

Side effects

• Renal failure
• Hypocalcemia