The very muscular and strong impact, but not equipped with appropriate skills taker Bruno was in 1982 made his debut in professional boxing. In 1985 he was European champion in the heavyweight division when he Andres Eklund in the fourth round KO suggested.
He suffered his first defeat against eventual WBA titlist James Smith. Clear in the lead lost Bruno in the tenth and final round by KO In 1986, his success was a knockout against former WBA champion Gerrie Coetzee in the first round.
His first world championship bout on 19 July 1986 against Bruno lost the WBA titlist Tim Witherspoon prematurely in round 11 In October 1987, he defeated Joe Bugner, former World Cup opponents of Muhammad Ali, in the 8th round.
The next World Cup chance came on February 25, 1989 against Mike Tyson. The fight for the title of the three associations WBC, WBA and IBF lost Bruno by knockout in the fifth round after the first round with hard hits he had hitherto dominant titleholder can bring in serious distress.
Four years later, Frank Bruno was another opportunity for a world championship boxing, the fight for the WBC title against Lennox Lewis in October 1993, he lost again early in round seven. ( After six rounds Bruno lay on a score sheet with 59 to 55 in the lead, the other two judges kept the fight up to that point with 57 to 57 for balance. )
In his fourth start on September 2, 1995 Frank Bruno was finally able to still win a world title. In London he defeated Oliver McCall, who had previously won a surprise against Lewis, on points. In the run he ended the collaboration with his longtime promoter Mickey Duff (1929-2014) and was taken by Don Kings damaligem European partners Frank Warren under contract.
His next and last fight played Bruno in March 1996 in Las Vegas against Mike Tyson, to whom he after a TKO in the third round, losing his title. In advance of the fight there were some conflicts, because actually Lennox Lewis would have been the mandatory challenger. Bruno accepted but as of the WBC wanted to fight Tyson, as he previously promised even better chance of winning this duel more money and after Tyson's weak performance against Buster Mathis. After this clear defeat in his first title defense Frank Bruno announced his retirement from boxing.