Fresh frozen plasma

Fresh frozen plasma (FFP also FFP of Engl. Fresh Frozen Plasma ) is a product obtained from donor blood products (blood product), which contains the liquid and dissolved constituents of the blood, while the cells of the blood ( erythrocytes, leukocytes, platelets) largely removed by centrifugation were.

Ingredients

GFPs included in physiological concentration

  • Inter alia albumin proteins
  • Factors of fibrinolysis
  • Factors of the complement system
  • Clotting factors
  • Immunoglobulins

Storage

GFPs are stored frozen and used for up to two years at -30 to -45 ° C.

Indication for the gift of GFP

  • Replacement of plasma with mass transfusion
  • Replacement of coagulation factor V and XI ( as these factors are not individually available as concentrates. )
  • Hepatic insufficiency with inadequate formation of clotting factors
  • With bleeding in the context of a coagulation ( As long as the case of consumption there is no bleeding, PCC are more likely to recommend. )
  • Plasma substitute in plasmapheresis

Dosage

GFP containing the coagulation factors of 500 ml of whole blood from a donor. This corresponds to about 10 % of the total blood volume. After thawing, the clotting activity is decreased to 70 % of the initial activity, it falls within hours then further drastically. According raises a GFP to the coagulation factors of the receiver by about 5-7 percentage points.

Rule of thumb:

Side effects

  • Allergic reactions
  • Infection. However, the risk of infection is low as compared to red blood cell concentrates, because the GFP is quarantine storage, ie, they will be released only if the donor is still published a second time to donate blood again and had no evidence of contagious diseases. However, the quarantine storage accesses for those infections to which the dispenser is also examined at the end of the quarantine storage (currently HIV, hepatitis B and C).
  • Frozen plasma contains antibodies against blood group that does not have the donor (for example, in the plasma of a donor group A there are antibodies against blood group B). These antibodies react with the red cells of the recipient and hemolysis occurs. The more frozen plasma is transfused, the greater the reaction. For this reason, frozen plasma is AB0 - compatible to transfuse. Plasma of group AB is an exception because it contains no antibodies after AB0 schema.
  • Therapeutic procedures in intensive care
  • Therapeutic procedures in hematology and oncology
  • Transfusion Medicine
363856
de