Frey's syndrome

The term Frey 's syndrome, also called syndrome Aurikulotemporales Gustatory sweating and Gustatory hyperhidrosis, refers to a abnormal pronounced sweating in circumscribed areas of the skin of the face and neck region, which is, during the consumption of any food or with gustatory ( d taste ) stimuli such as candy sucking, tasting, chewing, biting is triggered.

The Frey syndrome has been named after the Polish neurologist Łucja Frey- Gottesman (1889-1942), who described the disease in 1923. There are, however, already earlier descriptions of Duphenix (1757 ) and of Baillarger (1853 ) and is therefore sometimes also referred to as Frey- Baillarger syndrome.

Cause

The so-called " taste sweating" arises from the fact that autonomic parasympathetic ( secretory ) nerve impulses that one usually the salivary serving nerve branch ( chorda tympani ) of the seventh cranial nerve (facial nerve ) originate, were misguided. Thus it comes about after a trauma, surgery etc. under the Wiedereinsprossung, ie the regeneration of damaged nerves, to a new, faulty nerve contact ( sympathetic ) nerve fibers were actually created to sweat. Have Figuratively speaking, the ( the two nerve fiber types common chemical ) stimuli that are mediated by the transmitter substance acetylcholine, its original target organ, the salivary gland, and lost during the healing instead "accidentally" docked to the sweat glands. In any situation where there is usually salivation would be triggered, there is now therefore to sweat and you can view the patient suddenly from the outside, like them, " the mouth water runs ."

The symptoms are accordingly generally after surgery, after partial or complete removal of salivary glands shares, after a trauma, peripheral facial palsy or inflammation particularly of the parotid gland (Latin parotid gland ) or the submandibular gland (Latin submandibular gland ). In some case studies it has been observed after birth and usually interpreted as a result of birth trauma.

Therapy

By means of local injection of botulinum toxin A, the very debilitating for the affected people of gustatory sweating syndrome be treated effectively today.

Swell

  • L. Frey: Zespól nerwu uszno - skroniowego. In 1923.
  • L. Frey: Le syndrome du nerf auriculo - temporal. Revue neurologique, Paris 1923, 30 ( 2): 97-104
  • M. Duphenix: Observations sur les fistules du canal de salivaire Stenson. I. Sur une playe Compliqué à la joue ou le canal salivaire fut déchirée. Mémoires de l' Académie royale de chirurgie, 1757, III: 431-439.
  • JGF Baillarger: Mémoire sur l' obliteration du canal du Stenón. Gazette médicale de Paris, 1853, 23: 194-197
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