Fructose 6-phosphate

  • [( 2R, 3R, 4S) -3,4,5 -trihydroxy -5-( hydroxymethyl) - oxolane -2-yl ] methoxyphosphonsäure
  • Neuberg ester
  • C6H13O9P
  • C6H11O9P2 ( under physiological conditions )

Template: Infobox chemical / molecular formula search available

D-fructose -6-phosphate, a phosphoric acid ester of the fructose is a major metabolite of many metabolic processes. Under physiological conditions at a pH value of 7, the ester is present as anion (cf. picture).

Most important is its occurrence in glycolysis and gluconeogenesis and thus also in the alcoholic fermentation. Also, in the photosynthesis of the plants it plays a role in the Calvin cycle. Finally, the D-fructose -6-phosphate required for the biosynthesis of sucrose in plants.

There are two main derivatives, an intermediate of the glycolytic pathway and a regulator:

  • Fructose-1 ,6 -bisphosphate (FRC -1 ,6 -BP), the product of 1 phosphofructokinase ( PFK 1), the same substrate of the aldolase;
  • Fructose -2 ,6- bisphosphate (FRC -2 ,6 -BP), the product of 2 phosphofructokinase ( PFK 2), and at the same time an important activator of PFK 1
Carl Neuberg CAS registry number PubChem DrugBank Pasteur effect
323927
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