Fusidic acid

( 17Z ) - 16β -acetoxy- 3α, 11α -dihydroxy- ( 4α, 8α, 9β, 13α, 14β ) -29 - nordammara -17 ( 20) ,24 -dien- 21- acid

  • D06AX01
  • D09AA02
  • S01AA13

Colorless crystals

Antibiotics

192-193 ° C

Insoluble in ethanol, acetone, chloroform, sparingly soluble in water

Attention

1500 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Fusidic acid is a tetracyclic triterpenic with a 29 - Nordammaran backbone ( Fusidan ) from the fungus Fusidium coccineum that forms a bacteriostatic antibiotic by binding to an elongation factor (EF -G) protein synthesis at the bacterial ribosome.

Application

It is used mainly against infections of the skin and eyes due to staphylococci locally, but can also be administered as a tablet or infusion systemically.

Fusidic acid acts except for staphylococci on Neisseria, Clostridium, and Corynebacterium. Fusidic acid is not effective in gram-negative bacteria.

Fusidic acid also reaches well in bones and joints; it is metabolized in the liver and excreted via the bile.

Trade names

Fucidin (CH), Fucidin (D), Fucithalmic (D, A, CH), Fusicutan (D)

Fucicort (D, CH), Fucidin H ( CH)

CAS registry number Anatomical Therapeutic Chemical Classification System DrugBank Dangerous Substances Directive (67/548/EEC) Integrated Authority File
354929
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