Fusion protein

A fusion protein ( also known as hybrid protein) is produced by co-expression of two genes or gene parts, which lie behind one another in the genome. By removing the stop codons downstream of the first gene or through a merger by a chromosomal change (eg, translocation ) both genes are read as if it would be a single gene.

A well-known fusion protein that can be caused by a translocation of course, is the BCR -ABL gene product as the cause of chronic myeloid leukemia ( CML) is considered. The resulting shortened chromosome 22 is known as the Philadelphia chromosome.

In biochemistry fusion proteins artificially generated are often used in order to, for example, to examine the subcellular localization of a particular gene in the course of protein engineering or a protein to detect mild ( protein tag ). In this case, used as so called reporter protein commonly used fluorescent proteins, which are then fused to the C-or N-terminally to the protein to be examined.

Swell

• January Murken, Tiemo Grimm, and Elke Holinski - spring; Human Genetics; ISBN 978-3-13-139297-8