Gamma-Glutamylcarboxylase

The γ - Glutamylcarboxylase (or short: GGCX ) is an enzyme, glutamyl carboxylated special different proteins in the gamma position using the cofactor vitamin K and these proteins activates that. These include procoagulant factors ( II, VII, IX, X ), and the anticoagulant factors, such as the proteins C and S as well as proteins such as osteocalcin and Matrix Gla - protein, or ligands for receptor tyrosine kinases such as Gas6. This carboxylation of protein function, for example, requires the coagulation factors, because it allows their ability to bind calcium, and their binding to phospholipids.

GGCX is a membrane enzyme of the rough endoplasmic reticulum. GGCX contains 758 amino acids, is encoded in humans in the chromosome 2 gene locus p12. The gene contains 15 exons.

The enzyme catalyzes the following reaction ( but there is no free amino acids before, but these are part of a protein):

CO2 →

  • Ligase
Human Genome Organisation Cofactor (biochemistry) Fibrinolysis
269643
de