Gary Farmer was born in Ohsweken at Six Nations Reserve, as a member of the people of Cayuga.
Farmer played in many Canadian and American film and television productions. He was known primarily for its role as Nobody in Jim Jarmusch's Dead Man. He was twice awarded in 1989 for the role of Philbert Bono in Two Cheyenne on Highway and 1997 for Dead Man, from the American Indian Film Festival in San Francisco for Best Actor. In 1997 he was elected by First Americans in the Arts in Los Angeles, also for Dead Man, for Best Actor.
In 1993 he founded Aboriginal Voices, a magazine for the development of indigenous art and culture, and was until 1999 to adjust publishers. He is committed to the Native American culture as founder and director of Aboriginal Voices Radio, as well as an organizer of cultural festivals.
Gary Farmer is also active as a musician and filmmaker.