George Holcombe (* March 1786 in West Amwell, Hunterdon County, New Jersey; † January 14, 1828 in Allentown, New Jersey ) was an American politician. Between 1821 and 1828 he represented the State of New Jersey in the U.S. House of Representatives.
George Holcombe attended the common schools and then studied until 1805 at the Princeton College. After a subsequent medical studies at the University of Pennsylvania and Trenton he began in 1808 in Allentown to work in his new profession. He practiced there until 1815, and also held various local offices. At the same time he embarked on a political career. In the years 1815 and 1816 he was a member of the Democratic-Republican Party deputy in the New Jersey General Assembly.
In the congressional elections of 1820 Holcombe was for the third seat from New Jersey in the U.S. House of Representatives in Washington DC chosen, where he became the successor of Bernard Smith on March 4, 1821. After three re- elections he could remain until his death on January 14, 1828 in Congress. In the 1820s Holcombe joined the movement to the future President Andrew Jackson. In Congress, he experienced since about 1825, the violent clashes between the supporters and the Jacksons.
George Holcombe was buried in the cemetery Congress in the federal capital Washington.