Glucuronosyltransferase

• OMIM: 191740
• UniProt: P22309

UDP - glucuronosyltransferase (UDP - GT) is the name for enzymes that glucuronic acid from UDP - glucuronate on a small, hydrophobic molecule is transferred ( glucuronidation ). They are important in the degradation of harmful substances in the body. In particular the enzyme UDP GT1 A1 of human is required in large amounts in the liver at the porphyrin degradation. A lack of functional UDP - GT1 -A1 leads to hyperbilirubinemia and thus to the ( relatively harmless) Crohn's disease Meulengracht. Rare mutations in the UGT1A1 gene that lead to ( almost) utter defect in the enzyme that cause very severe courses of form of the disease, the Crigler- Najjar syndrome.

UDP -GT among the UDP - glycosyltransferases (UGT ) enzymes, a glycosyl- (sugar) groups transmitted by a UTP molecule to another small hydrophobic molecule. These enzymes are found in viruses, bacteria, plants and animals, where they are an important part of metabolism.