Glutathione reductase

Glutathione reductase ( GSR) (more precisely, glutathione reductase) is the enzyme glutathione disulfide (GSSG ) to glutathione (GSH ) is reduced. Here, a reduction equivalent (NADPH / H ) is consumed, which comes from the pentose phosphate pathway. The reaction takes place in animals, fungi, and various bacteria, and is used for recovery of glutathione, after it has been oxidized.

In humans, several splice variants of the enzyme occur, which differ in their localization ( in the mitochondria, cytosol ) differ from the GAP gene. Mutations in CSF can lead to reduced enzyme activity with hereditary hemolytic anemia.

Catalyzed reaction

NADPH / H   2x NADP

A molecule glutathione disulfide is reduced to two molecules of glutathione.

Protein isoform Human Genome Organisation Protein domain
269697
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