Goitrogen

Goitrogens or goitrogenic substances are substances which cause an enlargement of the thyroid (goiter, " goiter "). From the mechanism of action here they can be divided into two groups:

• Substances that inhibit iodine uptake ( iodination ) in the thyroid gland, as well as
• Substances that inhibit the formation of organic iodine compounds ( Iodisation ).

Iodinationshemmer

The many types of cabbage (Brassica spp.) Occurring glucosinolates ( glucosinolates ) are partly converted in the body to thiocyanates that reduce iodine uptake in the body. In addition, perchlorates act iodinationshemmend.

Therapeutically, this may increasingly be administered iodine.

Iodisationshemmer

Thiooxazolidone, such as the goitrin arise when glucosinolate metabolised by mustard oils that contain a hydroxy group at position 2. The antithyroid thiouracil, methylthiouracil, propylthiouracil prevent the iodination of tyrosine and thus the formation of thyroid hormones. The thyroid growth through the inclusion of such substances can only be treated by administration of thyroid hormones.