Grepafloxacin

  • (RS)- 1-cyclopropyl -6-fluoro -5-methyl -7 - (3- methylpiperazin -1-yl ) -4 - oxo-1 ,4- dihydroquinoline - 3-carboxylic acid (IUPAC)
  • Grepafloxacinum (Latin )

J01MA11

Antibiotics

Gyrase inhibitors

206-208 ° C

3029 mg · kg -1 ( LD50, Rat, oral, monohydrochloride )

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Grepafloxacin is a broad -spectrum antibiotic from the group of fluoroquinolones. Antibiotics from the group of fluoroquinolones are a sub- group of quinolones, they act as gyrase inhibitors against gram-positive bacteria ( Haemophilus, Legionella, mycoplasma, chlamydia and a), particularly in respiratory infections.

Grepafloxacin was from the pharmaceutical company Warner -Lambert (now Pfizer) patented in 1989. Once in some patients as a side effect long QT syndrome, a heart rhythm disorder, with seven deaths associated with the use of the drug occurred, it was taken by the manufacturer end of October 1999 from the world market.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank
279483
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