GRIA 2

  • OMIM: 138247
  • UniProt: P42262
  • MGI: 95809

The Glutamate receptor, ionotropic, AMPA 2, also known as GRIA2, is a human protein. Glutamate receptors are the predominant form of the excitatory neurotransmitter receptors in the mammalian brain. They are activated by a variety of neurophysiological processes. This membrane protein belongs to the family of glutamate receptors that are sensitive to alpha- amino-3- hydroxy-5- methyl-4- isoxazole propionate (AMPA ). It is a ligand- activated cation channel. These channels are composed of the four subunits Gria1 -4. (CAG -> CGG; Q -> R) in the gene of subunit GRIA2 an RNA editing described in the section which codes for the second transmembrane domain. Presumably, the channel is characterized Ca ( 2 )- impermeable. Studies in humans and animal studies suggest that the pre - mRNA editing for the normal function of the brain is essential and that any errors in RNA editing of GRIA2 gene play a role in the causation of ALS. This gene is an alternative splicing have been described what the formation of so-called flip-flop has the effect isoforms that differ in their signaling properties.

Protein isoform Human Genome Organisation Mouse Genome Informatics Entrez Ensembl National Center for Biotechnology Information RNA-Editing Amyotrophic lateral sclerosis AMPA receptor
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