Growth-hormone-releasing hormone

  • OMIM: 139 190
  • UniProt: P01286
  • MGI: 95709
  • CAS Number: 86168-78-7

Somatoliberin (growth hormone releasing hormone ) is a hormone formed in the hypothalamus, which is the formation and release of somatotropin ( GH ) (also growth hormone or Engl. Growth hormone (GH )) from the pituitary, stimulates. Other names for the hormone are growth hormone releasing hormone (GHRH, GRH ), somatotropin releasing hormone ( SRH SRF) and Somatokrinin.

Structure

The hormone is composed of 40 amino acids. It goes through proteolytic processing emerges from a prohormone which 108 amino acids is large. The locus of the coding DNA sequence is located on chromosome 20

Synthesis and secretion of

Somatoliberin is formed in neurosecretory cells of the ventromedial hypothalamus and in the arcuate nucleus and released in the median eminence of the hypothalamus and passes via the portal vessels in the adenohypophysis ( anterior pituitary gland ), where it excites the somatotroph cells to growth hormone release.

Also, pancreatic cancer can synthesize Somatoliberin and release.

Effect

The hormone stimulated by binding to the growth hormone releasing hormone receptor, the synthesis and secretion of somatotropin. It is a direct beneficiary deep sleep.

The opponent of the Somatoliberins is the somatostatin ( SRIH ).

Diseases

An excessive production of Somatoliberin can on enhanced secretion of somatotropin for gigantism, during growth and after the growth phase lead to acromegaly.

Doping

Somatoliberin is not currently detectable as a doping agent in conversation.

Protein isoform Human Genome Organisation Mouse Genome Informatics CAS registry number Anatomical Therapeutic Chemical Classification System DrugBank Euteleostomi Receptor antagonist
260026
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